# Thymulin papers

> Reading list — Functional Medicine Zurich — The Functional Medicine Zurich reading list covers thymulin's zinc chemistry, antibody recognition, human assays, ageing and experimental delivery.

**Reading list**

The chemistry is the starting point. Human samples, mouse tissue and treatment experiments give it different kinds of company.

## Begin with recognition

The [zinc-dependent epitope paper](https://pubmed.ncbi.nlm.nih.gov/2413455/) is my preferred entrance: the recognisable form and its biological activity are examined together. The [original metal-removal experiment](https://pubmed.ncbi.nlm.nih.gov/6957870/) and the [review of zinc-thymulin interactions](https://pubmed.ncbi.nlm.nih.gov/18476235/) supply the chemical context.

## Then change the experimental setting

The [human zinc-deficiency study](https://pubmed.ncbi.nlm.nih.gov/3262625/), [old-mouse organ culture](https://pubmed.ncbi.nlm.nih.gov/8582786/) and [mouse lung gene therapy](https://pubmed.ncbi.nlm.nih.gov/24556417/) are useful companions precisely because their materials differ. For the human intervention literature, my pair would be the [controlled nonathymulin trials](https://pubmed.ncbi.nlm.nih.gov/3310925/) beside the [open FTS-Zn trial](https://pubmed.ncbi.nlm.nih.gov/3427844/) for their different designs and preparations.

## References

[1] A zinc-dependent epitope on the molecule of thymulin, a thymic hormone https://pubmed.ncbi.nlm.nih.gov/2413455/
[2] Contribution of zinc and other metals to the biological activity of the serum thymic factor https://pubmed.ncbi.nlm.nih.gov/6957870/
[3] Interactions between zinc and thymulin https://pubmed.ncbi.nlm.nih.gov/18476235/
[4] Thymulin, a zinc-dependent hormone https://pubmed.ncbi.nlm.nih.gov/2657247/
[5] Induction of differentiation in human marrow T cell precursors by the synthetic serum thymic factor, FTS https://pubmed.ncbi.nlm.nih.gov/6969145/
[6] Serum thymulin in human zinc deficiency https://pubmed.ncbi.nlm.nih.gov/3262625/
[7] Distribution of age-related thymulin titres in normal subjects through the course of life https://pubmed.ncbi.nlm.nih.gov/10971509/
[8] Age-related thymus involution: zinc reverses in vitro the thymulin secretion defect https://pubmed.ncbi.nlm.nih.gov/8582786/
[9] Reversibility of the thymic involution and of age-related peripheral immune dysfunctions by zinc supplementation in old mice https://pubmed.ncbi.nlm.nih.gov/8582782/
[10] DNA nanoparticle-mediated thymulin gene therapy prevents airway remodeling in experimental allergic asthma https://pubmed.ncbi.nlm.nih.gov/24556417/
[11] Nonathymulin in rheumatoid arthritis: two double blind, placebo controlled trials https://pubmed.ncbi.nlm.nih.gov/3310925/
[12] An open trial of thymulin (FTS-Zn) in rheumatoid arthritis patients: sequential clinical and immunological follow-up https://pubmed.ncbi.nlm.nih.gov/3427844/
[13] Thymulin (FTS-Zn) induced in vitro modulation of T cell subsets markers on lymphocytes from rheumatoid arthritis and systemic lupus erythematosus patients https://pubmed.ncbi.nlm.nih.gov/6332789/

---

Functional Medicine Zurich gathers my arguments about published research on thymulin's working parts; it has no medical business behind it and provides no medical advice.